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A clinical pharmacological approach to the effective and safe use of tadalafil
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The mechanism of action leading to penile erection involves inhibition of PDE5, the major cyclic guanosine monophospate (cGMP) hydrolyzing enzyme located in the vascular smooth muscle cells of corpus cavernosum. Sexual stimulation triggers the release of the endothelium dependent relaxing factor nitric oxide (NO), stimulating through the protein kinase G the release of guanylyl cyclase […]
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