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Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Data Collection
The next session consisted of a cycle ergometry test similar to the first visit. However, during this second study, classical gas exchange measures were collected and subjects also were instructed to perform maximal expiratory flow volume (MEFV) maneuvers at rest and over the last 30 s of each work level (every 2 min). Since most […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults: Materials and Methods
These differences were not observed in children, suggesting the Arg16Gly polymorphism may influence the rate of decline in lung function with aging. The focus of the present study was to determine if common polymorphisms of the (P2AR differentially influence airway tone during and after short-term exercise in healthy subjects without asthma. We hypothesized that subjects […]
Influence of p2-Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults
The respiratory system adapts to changes in metabolic demand in an attempt to maintain gas exchange homeostasis at minimal cost. Among the many respiratory adaptations that occur during exercise is exercise-induced bronchodilation, the mechanism of which remains controversial.’2 Changes in airway tone with exercise, although small, are important, as it allows for a large increase […]
Diffusing Capacity for Nitric Oxide and Carbon Monoxide in Patients With Diffuse Parenchymal Lung Disease and Pulmonary Arterial Hypertension: Recommendation
An interesting study was performed by Bonay et al, who investigated whether the Vcap (determined with the single-breath high/low oxygen method) would be lower in subjects with DPLD and associated PAH than in subjects with DPLD without PAH. This appeared not to be the case, thus excluding the Vcap measurement as a screening test for […]
Diffusing Capacity for Nitric Oxide and Carbon Monoxide in Patients With Diffuse Parenchymal Lung Disease and Pulmonary Arterial Hypertension: Conclusion
There have been several studies dealing with the subdivision of the Dlco in interstitial lung diseases. In 1976, Saumon et al found that in patients with sarcoidosis with radiologic stage I and II disease, the decrease in Dlco was mainly due to decreased Dmco, but that in stage III sarcoidosis the decrease was associated with […]
Diffusing Capacity for Nitric Oxide and Carbon Monoxide in Patients With Diffuse Parenchymal Lung Disease and Pulmonary Arterial Hypertension: Discussion
In this prospective study, we found a difference in the Dlno/Dlco ratio between patients with DPLD and patients with PAH. Although this difference did reach statistical significance, the large overlap between the groups makes the Dlno/Dlco ratio inapplicable as a clinical tool in discriminating between PAH and DPLD. Although we used a lower inspiratory NO […]
Diffusing Capacity for Nitric Oxide and Carbon Monoxide in Patients With Diffuse Parenchymal Lung Disease and Pulmonary Arterial Hypertension: Results
The Dlco and Dlno were corrected to BTPS conditions, and a minimum of two measurements was performed, in which a variability of < 10% for the VA and Dlco was acceptable. All Dlco measurements were corrected to the standard Hb value according to American Thoracic Society recommendations. The obtained Dlno/ Dlco ratios were compared by […]